Current Trials
Fix Or Replace Enhancing distal humeruS fracTure outcomes. A multicentre UK-wide pragmatic prospective superiority randomised controlled trial comparing total elbow replacement versus fixation in patients aged 60 years and older with a distal humerus fracture.
- Chief Investigator: Prof Ben Ollivere (University of Nottingham)
- Co-Chief Investigator: Prof Andrew Duckworth
- Funder: NIHR (£2,030,369.63)
- Trial commenced: December 2023
- Current Status: Recruiting
RESTORE Trial. An international randomized controlled trial to evaluate AGN1 to prevent secondary hip fractures in osteoporotic women undergoing treatment of index hip fractures.
- Chief Investigator UK: Prof Andrew Duckworth
- Funder: Commercial (Agnovos Healthcare, LLC)
- Trial commenced: April 2021 (NCT04796350)
- Current Status: Recruiting
What is the clinical-effectiveness and cost-effectiveness of surgery with medial opening wedge high tibial osteotomy (HTO) compared with nonsurgical treatment in the management of osteoarthritis (OA) of the knee in patients younger than 60 years?
- Chief Investigator: Mr Anish Amin
- Co-Chief Investigator: Prof Andrew Duckworth
- Funder: NIHR (£1,833,804.93)
- Trial commenced: August 2022 (ISRCTN99042491)
- Current Status: Follow-up
Elderly Fixation of the Radius Radiological and Clinical Evaluation: A prospective randomised trial of surgical vs. conservative management in unstable distal radius fractures in patients aged 65 and older
- Chief Investigator: Prof Andrew Duckworth
- Funder: Scottish Orthopaedic Research Trust into Trauma (£100,000.00) and International Research Grant from Orthopaedic Trauma Association (OTA) (£14,554.52)
- Trial commenced: February 2022 (ISRCTN95922938)
- Current Status: Recruiting
The impact of REstrictive versUs Liberal Transfusion strategy on cardiac Injury in patients undergoing surgery for Hip Fracture
- Chief Investigator: Prof Mike Gillies
- Co-Chief Investigator: Prof Tim Walsh
- Principal Investigator RIE: Prof Andrew Duckworth
- Funder: NIHR (£1,859,371.32)
- Trial commenced: August 2021 (ISRCTN28818784)
Simple Olecranon Fracture Fixation: A multi-centre, parallel group, two arm, non-inferiority randomised controlled trial to compare clinical and cost-effectiveness of suture fixation versus tension band wiring for simple olecranon fracture fixation in adults
- Chief Investigator: Prof Adam Watts (Edge Hill University and Wrightington Upper Limb Unit)
- Co-applicant and PI: Prof Andrew Duckworth (No.1 Recruitment Site)
- Funder: NIHR (£1,737,362.39)
- Trial completed: December 2024 (ISRCTN87904264)
Humeral shaft fracture FIXation: A single centre prospective randomised controlled trial of operative versus non-operative management of fractures of the humeral diaphysis
- Funder: Scottish Orthopaedic Research Trust into Trauma (£100,000.00)
- Trial completed: October 2023 (NCT03689335)
- Oliver WM, Bell KR, Carter TH, Graham C, White TO, Clement ND, Duckworth AD**, Molyneux SG**. Operative vs Nonoperative Management of Fractures of the Humeral Diaphysis: The Humeral Shaft Fracture Fixation Randomized Clinical Trial. JAMA Surg. 2025 May 1; 160(5):508-516
Medial malleolus Operative Or Non-operative: A single centre prospective randomized controlled trial of operative versus nonoperative management of associated medial malleolus fractures in unstable fracture dislocations of the ankle joint
- Funder: Scottish Orthopaedic Research Trust into Trauma and Acumed® (£100,000.00)
- Trial completed: August 2021 (NCT03362229)
- Carter TH, Oliver WM, Bell KR, Graham C, Duckworth AD, White TO. Operative vs Nonoperative Management of Unstable Medial Malleolus Fractures: A Randomized Clinical Trial. JAMA Netw Open. 2024 Jan 2; 7(1):e2351308.
